ABSTRACT
Abstract Objetive: Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) improved symptoms and increased survival and quality of life in patients with coronary artery disease. However, it should be the main cause of a complex organic systemic inflammatory response that greatly contributes to several postoperative adverse effects. Methods: We aimed to evaluate heat-shock protein 70 (HSP 70) expression as a morbimortality predictor in patients with preserved ventricular function undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) and to determine their association with the lactate as a marker of tissue hypoperfusion and the EuroSCORE risk score. This is a prospective, observational study including 46 patients and occurring between May and July 2016. Patients without ventricular dysfunction undergoing myocardial revascularization with extracorporeal circulation were included. They were divided into (1) complicated and (2) uncomplicated postoperative evolution groups. EuroSCORE, lactate levels, and HSP 70 expression and their correlations were determined. Results: Statistical analysis showed that the group with complicated evolution had higher EuroSCORE values than the other group. HSP 70 protein levels were significantly increased in the group with uncomplicated evolution and showed similar results. According to our results, HSP family proteins may be independent predictors of uncomplicated evolution in patients without ventricular dysfunction undergoing CABG with CPB. Conclusion: HSP 70 should be a good discriminator and protection marker for complications in cardiac surgery.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Cardiopulmonary Bypass/mortality , Coronary Artery Bypass/mortality , Risk Assessment/methods , HSP70 Heat-Shock Proteins/analysis , Lactic Acid/blood , Preoperative Period , Postoperative Complications/etiology , Biomarkers/analysis , Cardiopulmonary Bypass/methods , Logistic Models , Blotting, Western , Coronary Artery Bypass/methods , Sensitivity and Specificity , Statistics, Nonparametric , Myocardium/pathologyABSTRACT
Abstract The heat shock proteins are endogenous proteins with the ability to act as molecular chaperones. Methods that provide cell protection by way of some damage can positively influence the results of surgery. The present review summarizes current knowledge concerning the cardioprotective role of the heat shock proteins as occurs in heart damage, including relevant information about the stresses that regulate the expression of these proteins and their potential role as biomarkers of heart disease.
Subject(s)
Humans , Myocardial Ischemia/metabolism , Myocytes, Cardiac/physiology , Cardiac Surgical Procedures , Heat-Shock Proteins/physiology , Biomarkers/metabolism , Heat-Shock Proteins/analysis , Myocardium/metabolism , Myocardium/chemistryABSTRACT
Objetivo: estimar a prevalência de alto risco da Síndromeda Apneia Obstrutiva do Sono e fatores associados,em adultos de uma capital do nordeste brasileiro. Materiaise Método: trata-se de um estudo observacional,transversal, que utilizou como instrumento de aferiçãoo Questionário de Berlim para uma amostra probabilísticacomposta por 574 indivíduos acima de 30 anos,residentes em Teresina, Piauí, Brasil. Com base nasrespostas do questionário, os indivíduos foram classificadosem alto e baixo risco para a Síndrome da ApneiaObstrutiva do Sono. Dados demográficos comoidade, gênero, peso e altura foram também obtidos.Teste Qui-Quadrado de Pearson e de regressão logística,com nível de significância de 5%, foram utilizadospara análise estatística. Resultados: observou-se prevalênciade alto risco da Síndrome da Apneia Obstrutivado Sono de 29,1%. Roncar, parar de respirar enquantoestá dormindo, acordar cansado, ficar cansado em seutempo desperto, Índice de Massa Corporal ≥ 30 kg/m2e hipertensão arterial são fatores significativos para ApneiaObstrutiva do Sono. Conclusão: o alto risco paraa Síndrome daApneia Obstrutiva do Sonofoi expressivoem indivíduos adultos de Teresina Piauí, sendo associadosignificativamente com os itens do questionáriode Berlim.